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Depakote tablets are meant for oral administration. Depakote tablets really should be swallowed whole and really should not be crushed or chewed.
In overdose scenarios, the portion of drug not certain to protein is significant and hemodialysis or tandem hemodialysis as well as hemoperfusion may possibly lead to sizeable elimination of drug.
Table three lists remedy-emergent adverse reactions which were being documented by ≥ five% of Depakote-treated people and for which the incidence was increased than inside the placebo group, within the placebo-controlled demo of adjunctive therapy for remedy of complex partial seizures.
It’s possible to have hair reduction being a facet outcome from having Depakote or Depakote ER. This aspect influence was claimed by people today using the medication to treat seizures or help avert migraine head aches. It wasn’t popular, nevertheless.
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Even so, the review authors noted that procedure efficacy wasn't connected with steps of nervousness, posttraumatic tension problem, sedation, or veteran versus nonveteran position. Alcoholic beverages use did not adjust due to remedy.
In clients in excess of two decades of age who are clinically suspected of getting a hereditary mitochondrial disorder, Depakote must only be read more utilised soon after other anticonvulsants have failed. This older group of patients should be intently monitored throughout remedy with Depakote for the event of acute liver injury with normal medical assessments and serum liver tests. POLG mutation screening need to be carried out in accordance with latest scientific practice [see Warnings and Safeguards (5.one)].
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This is particularly vital for Females setting up a pregnancy and for women at the onset of puberty; substitute therapeutic solutions should be viewed as for these patients [see Boxed Warning and Use in Particular Populations (eight.1)].
Naloxone has become described to reverse the CNS depressant consequences of valproate overdosage. Because naloxone could theoretically also reverse the antiepileptic outcomes of valproate, it ought to be employed with caution in sufferers with epilepsy.
Depakote dosage will vary. It will depend on the affected person as well as the affliction for which a health care provider prescribes it.